Gene regulatory landscape dissected by single-cell four-omics sequencing - Nature

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-zCombining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.